| ORIGINAL ARTICLE |
|
| Year : 2012 | Volume
: 18
| Issue : 2 | Page : 172-176 |
|
|
Association of microsatellite instability and chronic obstructive pulmonary disorder in isocyanate-exposed population of Bhopal
Protiti Bose, Rashmi Bathri
Department of Research, Cell and Molecular Biology Lab, Bhopal Memorial Hospital and Research Center, Karond Bye-pass Road, Bhopal, Madhya Pradesh, India
Correspondence Address:
Protiti Bose
HIG 7, Vanika, IIFM Staff Quaters, Kotra Sultanabad, Bhopal, Madhya Pradesh - 462038
India
 Source of Support: None, Conflict of Interest: None  | 3 |
DOI: 10.4103/0971-6866.100754
|
|
|
Context: Survivors of the Bhopal gas disaster still suffer from various respiratory ailments. We examined the effects of exposures among a cross-section of current residents suffering from COPD by ISSR-PCR.
Aims: Molecular screening of the gas-affected population of Bhopal with COPD for microsatellite instability due to exposure of MIC.
Settings and Design: The isocyanate-exposed population of Bhopal city suffering from chronic obstructive pulmonary disorder.
Materials and Methods: Inter-(SSR) analysis was used to characterize microsatellite instability in 52 MIC victims of Bhopal, suffering from COPD using (CA) 8 RG and (CA) 8 R[Y-Q] primer.
Statistical Analysis Used: Association analyses were performed using regression analysis.
Results: The study on the MIC-affected population in Bhopal showed weak association between microsatellite instability and age (r = + 0.37); exposure distance from site (r = −0.44); and smoking status(r = + 0.12); while regression analysis of the above parameters displayed supporting evidence.
Conclusions: The high prevalence of smoking coupled with aging and poor living habits threatens, to further increase COPD incidences among this population, highlighting the need for enhanced screening efforts. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
