| ORIGINAL ARTICLE |
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| Year : 2012 | Volume
: 18
| Issue : 3 | Page : 320-325 |
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The low frequency of Y chromosome microdeletions in subfertile males in a Sinhalese population of Sri Lanka
Tithila Kalum Wettasinghe, Rohan W Jayasekara, Vajira H. W. Dissanayake
Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
Correspondence Address:
Vajira H. W. Dissanayake
Professor and Medical Geneticist, Human Genetics Unit, Faculty of Medicine, University of Colombo, 271 Kynsey Road, Colombo 8
Sri Lanka
 Source of Support: This study was funded by a research grant from the Human Genetics Unit Development Fund, Faculty of Medicine, University of Colombo, Conflict of Interest: None
DOI: 10.4103/0971-6866.107985
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Aims: This study was designed to determine the prevalence of azoospermia factor (AZF) microdeletions on the Y chromosome in Sri Lankan Sinhalese infertile men with azoospermia and severe oligozoospermia.
Settings and Design: The patient group was 207 karyotypically normal infertile Sinhalese males.
Materials and Methods: The presence of 13 sequence-tagged site (STS) markers in the AZF region was tested using multiplex polymerase chain reaction (M-PCR). One hundred and twenty unselected men were also studied as a control group.
Results: Three (1.5%) had classic Y chromosome microdeletions in the AZFc sub-region.
Conclusions: These results suggest a much lower Y chromosome microdeletion frequency than previously thought, even among a strictly selected group of sub-fertile males in Sri Lanka. |
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