| CASE REPORT |
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| Year : 2012 | Volume
: 18
| Issue : 3 | Page : 359-362 |
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A case of oligoasthenoteratozoospermia with AZFc deletion and persistent oxidative stress
Rajender Singh1, Ahmad Mohammad Kaleem2, Sankhwar Satya Narayana3, Abbas Ali Mahdi2
1 Division of Endocrinology, Central Drug Research Institute, Lucknow, India
2 Department of Biochemistry, Chhatrapati Sahuji Maharaj Medical University, Lucknow, India
3 Department of Urology, Chhatrapati Sahuji Maharaj Medical University, Lucknow, India
Correspondence Address:
Rajender Singh
Division of Endocrinology, Central Drug Research Institute, Lucknow - 226 001, Uttar Pradesh
India
 Source of Support: Ministry of Health and Family Welfare (MOH and FW), Govt. of India,, Conflict of Interest: None  | 2 |
DOI: 10.4103/0971-6866.108037
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Y-chromosomal microdeletions are associated with severe oligozoospermia or azoospermia. AZFc microdeletions have been always associated with severe oligozoospermia or azoospermia with a rare occurrence in individuals with other infertility phenotypes. We report here a rare case of an infertile man carrying AZFc deletion, whose semen picture is oligoasthenoteratozoospermia complexed with seminal oxidative stress. Anti-oxidant therapy could make no change in either oxidative stress biomarker levels of semen, seminal parameters or serum hormone levels. Therefore, oligoasthenoteratozoospermia in the present case correlates with AZFc deletion, and high content of abnormal sperm eventually might be responsible for persistently elevated reactive oxygen species levels. Understanding the function of genes in AZFc region could help decipher the exact cause of the phenotype in such cases. |
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