| CASE REPORT |
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| Year : 2012 | Volume
: 18
| Issue : 3 | Page : 369-372 |
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A novel 11;18 translocation in a case of acute myeloid leukemia with maturation
G Sandhya Devi1, Faiq Ahmed1, Kavita Khadke1, Sudha S Murthy1, Senthil J Rajappa2
1 Department of Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India
2 Department of Medical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India
Correspondence Address:
G Sandhya Devi
Department of Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Rd No 14, Banjara Hills, Hyderabad - 500 034
India
 Source of Support: We would like to thank Mr. K Ramchander Reddy, Mrs. G. Jayashree, Mrs A Parameshwari, Mrs. M Padma, Miss D. Radhika for the technical support.,, Conflict of Interest: None
DOI: 10.4103/0971-6866.108050
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Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2. |
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