| REVIEW ARTICLE |
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| Year : 2013 | Volume
: 19
| Issue : 3 | Page : 282-290 |
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An overview of gene therapy in head and neck cancer
Amit Bali1, Deepika Bali2, Ashutosh Sharma1
1 Department of Oral and Maxillofacial Surgery, M.M. College of Dental Sciences and Research, Mullana, Ambala, Haryana, India
2 Department of Periodontics, DAV (C) Dental College and Hospital, Yamuna Nagar, Haryana, India
Correspondence Address:
Amit Bali
Department of Oral and Maxillofacial Surgery, M.M. College of Dental Sciences and Research, Mullana, Ambala, Haryana
India
 Source of Support: None, Conflict of Interest: None  | 2 |
DOI: 10.4103/0971-6866.120811
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Gene therapy is a new treatment modality in which new gene is introduced or existing gene is manipulated to cause cancer cell death or slow the growth of the tumor. In this review, we have discussed the different treatment approaches for cancer gene therapy; gene addition therapy, immunotherapy, gene therapy using oncolytic viruses, antisense ribonucleic acid (RNA) and RNA interference-based gene therapy. Clinical trials to date in head and neck cancer have shown evidence of gene transduction and expression, mediation of apoptosis and clinical response including pathological complete responses. The objective of this article is to provide an overview of the current available gene therapies for head and neck cancer. |
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