| CASE REPORT |
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| Year : 2013 | Volume
: 19
| Issue : 3 | Page : 352-354 |
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Hemoglobin Fontainebleau [a21(B2)Ala>Pro]: The second report from India
Ranjeet Singh Mashon1, Sona Nair2, Pratibha Sawant2, Roshan B Colah2, Kanjaksha Ghosh2, Sheila Das3
1 Department of Hematopathology, Christian Medical College, Ludhiana, Punjab, India
2 National Institute of Immunohaematology, Mumbai, Maharashtra, India
3 Department of Pathology, Christian Medical College, Ludhiana, Punjab, India
Correspondence Address:
Sheila Das
Department of Pathology, Christian Medical College, Ludhiana, Punjab - 141 008
India
 Source of Support: Financial support from Indian Council of Medical
Research for conducting this study, Conflict of Interest: None  | 2 |
DOI: 10.4103/0971-6866.120822
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Structural hemoglobin (Hb) variants are mainly due to point mutations in the globin genes resulting in single amino acid substitutions. Until date, about 200 alpha chain variants have been identified and they are usually detected during the hemoglobinopathy screening programs. Under a community control program for hemoglobinopathies, which involved screening of antenatal cases followed by prenatal diagnosis if indicated. Here, we report a rare alpha globin gene variant Hb Fontainebleau [a21(B2)Ala>Pro] detected in the heterozygous condition in a 35-year-old pregnant lady screened during this program. This is the second report of this alpha globin variant from India. Unlike the earlier case from India where Hb Fontainebleau was reported in a neonate who was also a carrier of Hb Sickle and had no clinical problems, this case presented with a bad obstetric history associated with the secondary infertility. However, the presence of the variant and the obstetric complications may be unrelated. |
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