CASE REPORT |
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Year : 2013 | Volume
: 19
| Issue : 3 | Page : 373-376 |
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Novel three missense mutations observed in Von Hippel-Lindau gene in a patient reported with renal cell carcinoma
Pasupuleti Santhosh Kumar1, Katari Venkatesh1, Lokanathan Srikanth1, Potukuchi Venkata Gurunadha Krishna Sarma1, Akkamgari Ramprasad Reddy2, Srinivasan Subramanian2, Bobbidi Venkata Phaneendra3
1 Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India 2 Department of Urology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India 3 Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
Correspondence Address:
Potukuchi Venkata Gurunadha Krishna Sarma Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences, Tirupati - 517 507, Andhra Pradesh India
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DOI: 10.4103/0971-6866.120809
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Von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary cancer syndrome that predisposes to the development of a variety of benign and malignant tumors, especially cerebellar hemangioblastomas, retinal angiomas and clear-cell renal cell carcinomas (RCC). We have identified of VHL gene using immunohistochemistry in a patient who was diagnosed for RCC. In order to understand the involvement of mutation in the VHL gene exon 1 was amplified and sequenced (accession number: JX 401534). The sequence analysis revealed the presence of novel missense mutations c.194 C>T, c.239 G>A, c.278 G>A, c.319 C>G, c. 337 C > G leading to the following variations p.Ala 65 Val, p.Gly 80 Asp, p.Gly 93 Glu, p.Gln 107 Glu, p.Gln 113 Glu in the protein. |
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