| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 19
| Issue : 4 | Page : 392-396 |
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Genetic variants in the cytochrome P450 2D6 gene in the Sri Lankan population
T. D. Praveen Tharanga1, C. M. V. Jinadasa2, MF Risama2, Priyadarshani Galappatthy1, RL Jayakody1, Vajira H. W. Dissanayake2
1 Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka
2 Department of Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka
Correspondence Address:
Vajira H. W. Dissanayake
Human Genetics Unit, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 00800
Sri Lanka
 Source of Support: By a Grant from them Improving Relevance and
Quality of Undergraduate Education Project, Faculty of Medicine, University
of Colombo, Sri Lanka, Conflict of Interest: None  | 3 |
DOI: 10.4103/0971-6866.124361
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Introduction: Cytochrome P450 2D6 (CYP2D6) enzymes are involved in the metabolism of a large number of commonly prescribed drugs such as antidepressants and cardiovascular drugs. The CYP2D6 *3, *4 and *14 variants associated with the loss of enzyme function; CYP2D6 *10 and *17 variants with reduced enzyme function; and CYP2D6 *2 variant with no effect on enzyme function. Establishing the frequency of these variant alleles in Sri Lankan population would be useful for optimizing pharmacotherapy with CYP2D6-substrate drugs.
Objective: The objective of this study was to determine the prevalence of CYP2D6 *2, *3, *4, *10, *14 and *17 variants in the main ethnic groups in the Sri Lankan population.
Materials and Methods: A total of 90 deoxyribonucleic acid (DNA) samples (30 each from Sinhalese, Tamils and Moors) were selected from a DNA resource at the Human Genetic Unit, Faculty of Medicine, University of Colombo. This collection had been made for population genetic studies from a random population based volunteers. Genotyping was performed using published polymerase chain reaction/restriction fragment length polymorphism methods.
Results: The prevalence of the CYP2D6 variants in Sinhalese, Sri Lankan Tamils and Moors respectively were CYP2D6 *2: 37%, 41.6% and 37.9%; CYP2D6 *3: 60.3%, 45% and 30%; CYP2D6 *4: 21.6%, 6.6% and 8.3%; CYP2D6 *10: 40%, 35% and 44%. CYP2D6 *14 and *17 variants were not identified.
Conclusion: CYP2D6 *3, *4 and *10 variants, which are associated with reduced or loss of CYP2D6 enzyme function were found in our population in significant frequencies. CYP2D6*4, which is reported to be a Caucasian variant was also found in all three ethnic groups. |
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