Indian Journal of Human Genetics
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CASE REPORT
Year : 2014  |  Volume : 20  |  Issue : 1  |  Page : 79-81

A novel chromosomal abnormality t (9;14)(p24;q13) in B-acute lymphoblastic leukemia


1 Division of Cancer Research, Regional Cancer Centre, Medical College, Trivandrum, Kerala, India
2 Division of Medical Oncology, Regional Cancer Centre, Medical College, Trivandrum, Kerala, India

Correspondence Address:
Sureshkumar Raveendran
Division of Cancer Research, Regional Cancer Centre, Medical College, Trivandrum 695 011, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.132763

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Acute lymphoblastic leukemia is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. We describe the clinical, morphologic, immunophenotypic and cytogenetic findings in the case of a 26-year-old man with B-lymphoblastic leukemia. Surface marker analysis revealed that they are positive for CD markers CD10, CD19, CD13, CD34, CD45 and HLA-DR, but negative for CD20, CD33, CD117 and CD11C markers. Cytogenetic analysis established a novel translocation, t (9;14)(p24;q13). Apart from this, spectral karyotyping revealed an additional translocation, t (6p; 14q). This is the first documented case of B-lymphoblastic leukemia with concurrent occurrence of both abnormalities. Further studies are needed to understand the role of this abnormality in carcinogenesis.


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