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Figure 2: Simple overview of folate and homocysteine metabolic cycles. AdoHcy, S-adenosylhomocysteine; Ado-Met, S-adenosylmethionine; BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine b-synthase; FR, folate receptor; MTHFD, methylenetetrahydrofolate dehydrogenase; MTHFR, methylenetetrahydrofolate reductase; MS, methionine synthase; MSR, methionine synthase reductase; RFC, reduced folate carrier; SHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate (39).

Figure 2: Simple overview of folate and homocysteine metabolic cycles. AdoHcy, S-adenosylhomocysteine; Ado-Met, S-adenosylmethionine; BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine b-synthase; FR, folate receptor; MTHFD, methylenetetrahydrofolate dehydrogenase; MTHFR, methylenetetrahydrofolate reductase; MS, methionine synthase; MSR, methionine synthase reductase; RFC, reduced folate carrier; SHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate (39).