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Figure 1: CYP2C9/VKORC1 genotype profile and (inset) frequency of coumarin-response genotype groups in subjects at high risk for thrombophilia (FVL carriers): Individuals with two variant CYP2C9/VKORC1 genotypes (either compound heterozygous or homozygous) were grouped as 'hyper' sensitive (included *2 * 3/GG; *1 * 3/AG, *1 * 2/AG and *1 *1/AA) and are indicated by grey bars. Those with single heterozygous polymorphism including *1 * 1/AG; *1 *2/GG, and *1 * 3/GG were grouped to have 'moderate' sensitivity and are indicated with dark grey bars. The wild-type CYP2C9/VKORC1 (*1 *1/GG) are indicated with black bars and comprise those with 'normal' sensitivity. The inset bar graph depicts the total frequency of the three estimated coumarin sensitivity groups

Figure 1: <i>CYP2C9</i>/<i>VKORC1</i> genotype profile and (inset) frequency of coumarin-response genotype groups in subjects at high risk for thrombophilia (FVL carriers): Individuals with two variant <i>CYP2C9/VKORC1</i> genotypes (either compound heterozygous or homozygous) were grouped as 'hyper' sensitive (included *2 * 3/GG; *1 * 3/AG, *1 * 2/AG and *1 *1/AA) and are indicated by grey bars. Those with single heterozygous polymorphism including *1 * 1/AG; *1 *2/GG, and *1 * 3/GG were grouped to have 'moderate' sensitivity and are indicated with dark grey bars. The wild-type <i>CYP2C9/VKORC1</i> (*1 *1/GG) are indicated with black bars and comprise those with 'normal' sensitivity. The inset bar graph depicts the total frequency of the three estimated coumarin sensitivity groups