Figure 4: Pedigree of family papillary and follicular, with haplotype analysis in the region of linkage to susceptibility to thyroid cancer and TCO, on chromosome 19. Circles represent females, and squares represent males; crossed symbols denote cases of thyroid cancer. Critical recombination in individuals II-2, II-3 and II-4 define a 1 - 1-0 - 1-1 haplotype that is co- inherited with the disease and that is not shared by the unaffected family members