• Users Online: 715
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
CASE REPORT
Year : 2014  |  Volume : 9  |  Issue : 4  |  Page : 163-164

Targeted therapy in triple-negative breast cancer: A case series


1 Department of Hematology and Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Nursing, Borujerd Branch, Islamic Azad University, Borujerd, Iran
3 Department of Pharmacology, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Mehrdad Payandeh
Department of Hematology and Oncology, Kermanshah University of Medical Sciences, Kermanshah
Iran
Login to access the Email id


DOI: 10.4103/1858-5000.153032

Rights and Permissions

At least 20% of breast cancers are characterized by triple-negative receptor status (negative for estrogen receptor, progesterone receptor, and HER2). Human epidermal growth-factor receptor (EGFR) is a member of the EGFR/ErbB/HER family of Type I transmembrane tyrosine kinase receptors. Nine patients had TN-EGFR-positive with metastatic breast cancer (MBC). EGFR positivity was defined as staining in >10% of tumor cells by Immunohistochemistry. In total, nine patients were enrolled that the mean age was 46.7 years. All patients were from Kurdish ethnicity in west of Iran. Patients received erlotinib 150 mg daily. This suggests there may be a subset of TN, EGFR-positive MBC for whom EGFR-directed therapy may be suitable or that the natural history of their disease was indolent. Future studies to determine molecular and clinical profiles of patients likely to benefit from EGFR-tyrosine kinase inhibitor therapy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed842    
    Printed28    
    Emailed0    
    PDF Downloaded79    
    Comments [Add]    

Recommend this journal