|
Study of bone markers in hyperthyroidism: Single center experience from South India
Babulreddy Hanmayyagari1, Mounika Guntaka2, Rakesh Sahay3, Jayanthy Ramesh3, Sri Nagesh4
1 Department of Endocrinology, Krishna Institute of Medical Sciences, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India
2 Department of Biochemistry, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India
3 Department of Endocrinology, Osmania General Hospital, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India
4 Department of Endocrinology, Care Hospital, Hyderabad, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India
Correspondence Address:
Babulreddy Hanmayyagari
Flat No. A 904, Sri Sai Ram Towers, Beside Alwyn Colony Water Tank, Hafeezpet, Hyderabad - 500 049, Telangana
India
  | Check |
DOI: 10.4103/1858-5000.167867 
|
|
Aim: To evaluate bone health markers and Vitamin D status in patients with hyperthyroidism comprehensively, and comparison of same with matched controls. Materials and Methods: The study has been done on 30 newly diagnosed hyperthyroid patients and matched controls. Cases were selected after careful exclusion of conditions which adversely affect bone health. Statistical comparisons were performed with Student's t-test. Results: The study group has shown normal calcium (20% had hypocalcemia), normal phosphorus, normal parathyroid hormone values, raised alkaline phosphatase levels, and significant rise in both bone formation (osteocalcin) and resorption (β-cross laps) markers (P < 0.05). In addition, 95% of our subjects (patients and controls) were Vitamin D deficient (mean - 17.2 ng/dl). Conclusion: Hyperthyroidism is associated with increased rate of bone remodeling and changes in mineral homeostasis, thereby increases fracture risk. Associated Vitamin D deficiency further deteriorates bone quality. Hence, we suggest therapeutic Vitamin D and calcium supplementation is needed in addition to antithyroid medication. |
