BoneKEy-Osteovision | Perspective

Myeloma-bone interaction: A vicious cycle

Toshio Matsumoto
Masahiro Abe

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DOI:10.1138/20060202

Abstract

Multiple myeloma is a disease that results in devastating bone destruction. Myeloma cells stimulate bone resorption through the enhancement of osteoclast formation and activation. These effects are mediated through the impact of macrophage inflammatory protein (MIP)-1 on RANKL-RANK signaling. Bone marrow stromal cells, as well as the interaction between myeloma cells and osteoclasts, contribute to the growth and survival of myeloma cells. B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) play important roles in the interaction between myeloma cells and osteoclasts. Myeloma cells also suppress bone formation through the secretion of Wnt antagonists, including secreted Frizzled-related protein (sFRP)-2. An understanding of the molecular mechanism of bone destruction and tumor progression in multiple myeloma is necessary to develop effective therapies for myeloma patients.

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