BoneKEy-Osteovision | Perspective
BMP and its antagonists
Masaki Noda
DOI:10.1138/20060205
Abstract
Bone morphogenetic protein (BMP) is necessary for the development of mesenchymal tissue and mesoderm formation during development. BMP2 and BMP4 play critical roles in morphogenesis. On the other hand, BMP5, BMP6 and BMP7, which were discovered more recently, likely serve as specific modulators of the development of other tissues. There are several inhibitory molecules that seem able to target BMP functioning, including SOST, Tob, CIZ and Noggin. These molecules appear to help determine the levels of bone mass in adult mice. Further analysis is necessary to elucidate the specific functions of BMP inhibitors and BMPs in adult bone.
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