Journal Facts

Journal
BoneKEy Knowledge Environment
ISSN
1533-4368
Volume
3
Year
2006

Article Facts

Title
Meta-analysis of osteoporosis genetic studies – much ado about nothing?
DOI
10.1138/20060221
Authors

Matthew A Brown

Online Date
07/00/2006

Article Links

BoneKEy-Osteovision | Perspective

Meta-analysis of osteoporosis genetic studies – much ado about nothing?

Matthew A Brown


DOI:10.1138/20060221

Abstract

Meta-analysis is an increasingly used tool in many areas of biomedical research. There are very few fields of research where there is no conflict in the published literature, or where there are unarguably definitive studies available. This is particularly the case in genetics, where, for reasons outlined elsewhere, current approaches have been plagued by high false discovery rates and inadequate power. Not surprisingly, some investigators have turned to meta-analysis to address these problems. This review examines the strengths and weaknesses of the different forms of meta-analysis, with a particular focus on their record and potential future role in osteoporosis genetics.

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