Journal Facts

Journal
BoneKEy Knowledge Environment
ISSN
1533-4368
Volume
3
Year
2006

Article Facts

Title
Selective prostaglandin agonists as anabolic agents
DOI
10.1138/20060222
Authors

Lawrence G Raisz

Online Date
07/00/2006

Article Links

BoneKEy-Osteovision | Perspective

Selective prostaglandin agonists as anabolic agents

Lawrence G Raisz


DOI:10.1138/20060222

Abstract

Although the ability of prostaglandins to stimulate bone formation was demonstrated more than 30 years ago, it has been difficult to develop clinical applications, largely because of the multiplicity of prostaglandin actions. The development of selective agonists for prostaglandin receptors, particularly the prostaglandin E2 receptors, EP2 and EP4, has made it possible to characterize the anabolic pathway and to explore these agonists as therapeutic agents. Studies in experimental animals suggest that both agonists might be used locally to accelerate fracture repair or heal skeletal defects or systemically to stimulate bone formation in osteoporosis.

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