BoneKEy-Osteovision | Perspective

Bisphosphonates and γδ t-cells: New insights into old drugs

Keith Thompson
Michael J Rogers

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DOI:10.1138/20060224

Abstract

Bisphosphonates (BPs) are now well established as front-line treatments for post-menopausal osteoporosis, Paget's disease and tumor-associated osteolysis and hypercalcemia. Since the basic pharmacology and mechanisms of action of these bone-targeting agents have been reviewed in detail elsewhere (), we summarize new insights into their mode of inhibition of FPP synthase, concepts of their anti-resorptive effects on osteoclasts and, in particular, discuss their recently-discovered effects on γδ T-cells and prospects for their future use as immune therapies.

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