BoneKEy-Osteovision | Perspective

New agents for the treatment of osteoporosis

T John Martin
Kong Wah Ng

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DOI:10.1138/20070279

Abstract

Discoveries in bone biology are directing early efforts to find new drugs for the treatment of osteoporosis. For anti-resorptive therapy, much current attention is aimed at inhibiting osteoclast activity, in some cases even doing so without inhibiting bone formation as a coupled response. Human and mouse genetics have provided fascinating possibilities for new anabolic agents by identifying the activated Wnt signaling pathway as a key process in the regulation of osteoblast differentiation and bone formation.

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