Journal Facts

Journal
BoneKEy Knowledge Environment
ISSN
1940-8692
Volume
6
Year
2009

Article Facts

Title
The role of BMPs in current orthopedic practice
DOI
10.1138/20090386
Authors

Gerhard Schmidmaier
Britt Wildemann

Online Date
07/00/2009

Article Links

IBMS BoneKEy | Perspective

The role of BMPs in current orthopedic practice

Gerhard Schmidmaier
Britt Wildemann


DOI:10.1138/20090386

Abstract

Bone morphogenetic proteins (BMPs) have been applied successfully in the clinic for the treatment of spinal fusion, fracture healing, and delayed and non-unions. Demographic data reveal that because of the steadily rising age of the population, complications related to the musculoskeletal system will increase during the coming years. Multiple in vitro and in vivo studies, as well as clinical trials, clearly show a strong osteoinductive effect of BMP-2 and BMP-7. In comparison to the “gold standard” autologous bone graft, BMPs seem to be as good as the iliac crest bone graft (ICBG) or even more effective, and the side effects are moderate. Today BMPs play an increasingly important role in orthopedic practice. Further improvement of application systems might lower the risk of side effects and could improve outcome parameters.

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