Journal Facts

Journal
BoneKEy Knowledge Environment
ISSN
1940-8692
Volume
7
Year
2010

Article Facts

Title
FGF23: Phosphate metabolism and beyond
DOI
10.1138/20100458
Authors

Seiji Fukumoto

Online Date
08/00/2010

Article Links

IBMS BoneKEy | Perspective

FGF23: Phosphate metabolism and beyond

Seiji Fukumoto


DOI:10.1138/20100458

Abstract

FGF23 was identified as a humoral factor involved in the development of several hypophosphatemic diseases about 10 years ago. Since then, it has been shown that FGF23 is produced by bone and works as a hormone to reduce phosphate and 1,25-dihydroxyvitamin D levels by binding to a Klotho-FGF receptor complex. Therefore, deficient actions of FGF23 result in a disease with hyperphosphatemia and high 1,25-dihydroxyvitamin D. In addition, FGF23 is one of the key players in the development of chronic kidney disease-mineral and bone disorder (CKD-MBD). Recent studies also suggest that high circulatory FGF23 is associated with an increased risk of cardiovascular events and mortality. However, there still remain many unanswered questions about FGF23. This Perspective summarizes both the current state of knowledge of FGF23, as well as gaps in our understanding.

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