Email this article Is Fat Tissue a Suitable Source of Stem Cells for Musculoskeletal Regenerative Medicine Therapies: Literature Review
Abstract
This review found that adipose-derived stem cells are suitable for treating osteoarthritis. Besides joint replacement the current treatments do not reverse the underlining pathology, whereas this therapy replaces lost or damaged tissue and could represent a cure. Bone marrow is the traditional source of stem cells, however adipose tissue is more appropriate because of ease of harvesting, abundance, the concentration of stem cells and potential cosmetic benefits. Subcutaneous fat-derived stem cells are more effective for treating osteoarthritis when compared to visceral fat-derived. Human and animal models have shown its efficacy but with limitations. It has been less successful in older and/or patients with greater joint degeneration. Its cost-effectiveness when compared to current treatment has not been shown. A gold standard production and implantation method have yet to be developed, meaning there are no guidelines for its use. Current studies aim to address these issues, with implementation on the horizon.
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References
Mason C and Dunnill P. A brief definition of regenerative medicine. Regen Medicine. 2008, Jan; 3(1): 1–5.
State of Musculoskeletal Health 2018 [ebook]. Chesterfield: Arthritis Research UK; 2018 [cited 2019 Mar 13] Available from: https://www.arthritisresearchuk.org/~/media/Files/Data%20and%20stats/State%20of%20MSK/PHS-08_StateOfMSKReport.ashx.
Martin E. Oxford Concise Medical Dictionary. 9th ed. Oxford: Oxford University Press; 2015.
Nice.org.uk [Internet] [updated 2014; cited 2019 Feb 27] Available from: https://www.nice.org.uk/guidance/cg177/resources/osteoarthritis-care-and-management-pdf-35109757272517.
Nice.org.uk [Internet] [updated 2014; cited 2019 Mar 10] Available from: https://www.nice.org.uk/guidance/cg177/documents/osteoarthritis-update-final-scope2.
Young B, Lowe J, Stevens A, Heath J and Deakin P. Wheater's Functional Histology. 5th ed. Philadelphia, PA: Churchill Livingstone/Elsevier; 2014
Borrud L, Flegal K, Looker A, Everhart J, Harris T and Shepherd J. Body composition data for individuals 8 years of age and older: U.S. population, 1999–2004. NCHS. 2010, Apr, Vital Health Statistics 11(250).
Naish J, Revest P and Syndercombe Court D. Medical sciences. Edinburgh: Saunders/Elsevier; 2009.
Yoshimura K, Shigeura T, Matsumoto D, Sato T, Takaki Y, Aiba-Kojima E, Sato K, Inoue K, Nagase T, Koshima I and Gonda K. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol. 2006, Jan 31; 208(1):64-76.
American Society of Plastic Surgeons. Plastic Surgery Statistics Report. [internet] [updated 2018; cited 2019 Feb 15] Available from: https://www.plasticsurgery.org/documents/News/Statistics/2017/plastic-surgery-statistics-report-2017.pdf.
BAAPS. Cosmetic Surgery Stats: Dad Bods And Filter Jobs. [internet] [updated 2018; cited 2019 Feb 15] Available from: https://baaps.org.uk/about/news/1535/cosmetic_surgery_stats_dad_bods_and_filter_jobs.
Gimble J, Katz A and Bunnell B. Adipose-Derived Stem Cells for Regenerative Medicine. Circ Res. 207 May 11; 100(9): 1249-1260.
van Harmelen V, Skurk T and Hauner H. Primary culture and differentiation of human adipocyte precursor cells. Methods Mol Med. 2005; 107: 125–135.
Mohamed-Ahmed S, Fristad I, Lie S, Suliman S, Mustafa K, Vindenes H and Idris S. Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison. Stem Cell Res Ther. 2018 Jun 19; 9(1): 169.
Zhu Y, Liu T, Song K, Fan X, Ma X and Cui Z. (2008). Adipose-derived stem cell: A better stem cell than BMSC. Cell Res. 2008; 18(S1):165-165.
Liao H. Osteogenic potential: Comparison between bone marrow and adipose-derived mesenchymal stem cells. World J Stem Cells. 2014 Jul 26; 6(3): 288-295.
Tang Y, Pan Z, Zou Y, He Y, Yang P, Tang Q and Yin F. A comparative assessment of adipose-derived stem cells from subcutaneous and visceral fat as a potential cell source for knee osteoarthritis treatment. J Cell Mol Med. 2017 Sep; 21(9): 2153-2162.
Jurgens W, Oedayrajsingh-Varma M, Helder M, ZandiehDoulabi B, Schouten T, Kuik D, Ritt M and van Milligen F. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies. Cell Tissue Res. 2008 Jun; 332(3): 415-426.
Raposio E, Simonacci F and Perrotta R. Adipose-derived stem cells: Comparison between two methods of isolation for clinical applications. Ann Med Surg (Lond). 2017 Aug; 20: 87-91.
Gittel C, Brehm W, Burk J, Juelke H, Staszyk C and Ribitsch IIsolation of equine multipotent mesenchymal stromal cells by enzymatic tissue digestion or explant technique: comparison of cellular properties. BMC Veterinary Res. 2013 Oct 29; 9 (221).
Megaloikonomos P, Panagopoulos G, Bami M, Igoumenou V, Dimopoulos L, Milonaki A, Kyriakidou M, Mitsiokapa E, Anastassopoulou J and Mavrogenis A. Harvesting, Isolation and Differentiation of Rat Adipose-Derived Stem Cells. Curr Pharm Biotechnol. 2018 Apr 13; 19: 19-29.
Harasn H, Mariya S, Sajuti D, Islam A, Wahjoepramono E and Yusuf I. Isolation of Mesenchymal Stem Cells from Adipose Tissue. InaBJ. 2015; 7(3): 153-156.
Aronowitz J, Lockhart R and Hakakian C. Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue. SpringerPlus. 2015; 4: 713.
Raposio E, Caruana G, Bonomini S, and Libondi G. A novel and effective strategy for the isolation of adipose-derived stem cells: minimally manipulated adipose-derived stem cells for more rapid and safe stem cell therapy. Plast Reconstr Surg. 2014 Jun; 133(6): 1406–1409.
Jing W, Xiao J, Xiong Z, Yang X, Huang Y, Zhou M, Chen S, Lin Y and Tian W. Explant culture: An efficient method to isolate adipose-derived stromal cells for tissue engineering. Artif Organs. 2011 Feb; 35(2): 105-112.
Oarsi.org. Physician Summary Non- Surgical Treatment of Osteoarthritis of the Knee. [Internet] [updated 2018; cited 2019 Feb 27] Available from: https://www.oarsi.org/sites/default/files/library/2014/pdf/physiciansumfinal.pdf.
Fransen M, McConnell S, Harmer A, Van der Esch M, Simic M and Bennell K. Exercise for osteoarthritis of the knee. Cochrane Database of Systematic Reviews. Br J Sport Med. 2015 Dec; 49(24): 1554-1557.
Bellamy N, Campbell J, Welch V, Gee T L, Bourne R and Wells G A. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database of Syst Rev. 2006 Apr 19; 2.
Henriksen M, Hansen J, Klokker L, Bliddal H and Christense R. Exercise versus analgesics for knee osteoarthritis pain: A meta-epidemiological study of Cochrane systematic reviews. J Comp Eff Res. 2016 Jul; 5(4): 417-431.
Murphy J, Fink D, Hunziker E and Barry F. Stem cell therapy in a caprine model of osteoarthritis. Arthritis & Amp. 2003 Dec 08; 48(12): 3464-3474.
Toghraie F, Chenari N, Gholipour M, Faghih Z, Torabinejad S, Dehghani S and Ghaderi A. Treatment of osteoarthritis with infrapatellar fat pad derived mesenchymal stem cells in Rabbit. Knee. 2011 Mar; 18(2): 71-75.
Shah K, Drury T, Roic I, Hansen P, Malin M, Boyd R, Sumer H and Ferguson R. Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects. Stem Cells Int. 2018 Jun 28; 2018: pp.1-7.
Black L, James G, Adams C, Dhupa S, Sams A, Taylor R, Harman S, Gingerich D and Harman R. Effect of Intraarticular Injection of Autologous AdiposeDerived Mesenchymal Stem and Regenerative Cells on Clinical Signs of Chronic Osteoarthritis of the Elbow Joint in Dogs. Veterinary therapeutics: research in applied veterinary medicine. 2008 Feb; 9(3): 192-200.
Mariñas-Pardo L, García-Castro J, Rodríguez-Hurtado I, Rodríguez-García M, Núñez-Naveira L and Hermida-Prieto M. Allogeneic Adipose-Derived Mesenchymal Stem Cells (Horse Allo 20) for the Treatment of Osteoarthritis-Associated Lameness in Horses: Characterization, Safety, and Efficacy of Intra-Articular Treatment. Stem Cells Dev. 2018 Sep 1; 27(17):1147-1160.
Delling U, Brehm W, Ludewig E, Winter K and Julke H. Longitudinal Evaluation of Effects of Intra-Articular Mesenchymal Stromal Cell Administration for the Treatment of Osteoarthritis in an Ovine Model. 2014 Dec 21; 24: 2391-2407.
Ding C. Do NSAIDs Affect the Progression of Osteoarthritis? Inflammation. 2002 June; 26(3): 139-142
Kim Y, Kwon O, Choi Y, Suh D, Heo D and Koh Y. Comparative Matched-Pair Analysis of the Injection Versus Implantation of Mesenchymal Stem Cells for Knee Osteoarthritis. Am J Sports. 2015 Sep 3; 43(11): 2738-2746.
Kim Y, Choi Y, Suh D, Heo D, Kim Y, Ryu J and Koh Y. Mesenchymal Stem Cell Implantation in Osteoarthritic Knees: Is Fibrine Glue Effective a scaffold. Am J Sports. 2015 Jan; 43(1): 176-185.
Snyder T, Madhavan K, Intrator M, Dregalla R and Park D. A fibrin/hyaluronic acid hydrogel for the delivery of mesenchymal stem cells and potential for articular cartilage repair. J Med Biol Eng. 2014 May 01; 8(1): 10.
Song Y, Du H, Dai C, Zhang L, Li S, Hunter D, Lu L and Bao C. Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections. Regen Med. 2018 Apr; 13(3): 295-307.
Toyserkani N, Jørgensen M, Tabatabaeifar S, Jensen C, Sheikh S and Sørensen J. Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events. Stem Cells Transl Med. 2017 Sep; 6(9): 1786-1794.
Kim Y, Choi Y and Koh Y. Mesenchymal Stem Cell Implantation in Knee Osteoarthritis: An Assessment of the Factors Influencing Clinical Outcomes. Am J Sports. 2015 June 25; 43(9): 2293-2301.
Stan G, Orban H and Orban C. Cost Effectiveness Analysis of Knee Osteoarthritis Treatment. Chirurgia (Bucur). 2015 Jul-Aug; 110(4): 368-374.
Wang S, Ganguli A, Macaulay D, Reichmann W, Medema J and Cifaldi M. The economic burden of osteoarthritis in Americans: analysis from a privately insured population. Osteoarthritis and Cartilage. 2013; 22: S210.
Alcerro J and Lavernia C. Stem Cells and Platelet-rich Plasma for Knee Osteoarthritis. J Am Acad Orthop Surg. 2018 Nov 28.
Clinicaltrials.gov. ClinicalTrials.gov. [Internet] [updated 2019; cited 2019 Feb 16] Available from: https://www.clinicaltrials.gov/
Fda.gov. StemGenex Biologic Laboratories, LLC 10/31/18. [Internet] [cited 2019 Mar 4] Available from: https://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm625497.htm
DOI: http://dx.doi.org/10.7227/MMJ.0030
Copyright (c) 2020 Matthew James Hennessy
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