Serotonin 5-HT₂ Receptors: Molecular and Genomic Diversity

Non-synonymous 5-HT_2A R SNPs. A. Distribution of SNPs in the 5-HT_2AR. Asterisks indicate sites of amino acid changes. B. Maximum PI hydrolysis response of NIH3T3 cells stably expressing 5-HT_2AR variants; cells were treated with varying concentrations of 5-HT for 30 minutes to generate full dose-response curves. Data represent the maximum response obtained following drug treatment (n=5).