RHO SIGNALING in Vascular Diseases

Hypertensive implications of Rho signaling. Rho decreases the mRNA stability of eNOS, which would thereby reduce NO production and subsequent cGMP-dependent signaling; a reduction of the inhibitory effect of cGMP on Rho activation would result in increased Rho signaling. In the schematic, arrows indicate processes of activation; blunt arrows represent inhibitory processes. Because the signaling scheme contains two blunt arrows, a positive feedback loop centers around Rho, resulting in contraction, migration, and DNA synthesis.