Cyclic Nucleotide Signaling Mechanisms in Trypanosomes: Possible Targets for Therapeutic Agents

The life cycle ofT. brucei. The trypanosome T. brucei, the causative agent of Afrtican sleeping sickness is capable of living in an arthropod vector (tsetse fly) and in humans. Thus it is no wonder the parasite has a very complex life cycle allowing it to survive (and thrive) in its hosts. Trypanosomes drawn for illustrative purposes only and lack particular details specific to each stage.