IBMS BoneKEy | Perspective

Chronic kidney disease-mineral bone disorder (CKD-MBD)

Kraiwiporn Kiattisunthorn
Sharon M Moe

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DOI:10.1138/20100479

Abstract

Chronic kidney disease-mineral bone disorder (CKD-MBD) is a new term to describe the complex interplay of abnormal mineral metabolism, increased bone fragility and impaired linear bone growth, and vascular calcification in patients with CKD. These abnormalities are more common, and the natural history accelerated, in the setting of CKD. All components of CKD-MBD are associated with increased morbidity and mortality. The pathophysiology of CKD-MBD is just beginning to be understood, offering hope for new therapies to reduce the burden of fractures and cardiovascular disease in patients with CKD.

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