Potassium Channel Subunits: The MiRP Family

MiRP2 accelerates inactivation recovery of Kv3.4 channels. Representative low current density on membrane patches from CHO cells expressing Kv3.4 or MiRP2/Kv3.4 cannels during a train of 1-s repetitive pulses to +60 mV from a holding voltage of –80 mV (protocol in inset). Wherease Kv3.4 channels show re-openings at –80 mV following depolarization as they recover slowly from inactivation, MiRP2/Kv3.4 channels recover more quickly and re-openings are not visible.