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The secretases, proteolytic activities that contribute to the molecular etiology of Alzheimer disease, are being intensively investigated as possible therapeutic targets. The investigation of these proteases is also yielding new insights into basic mechanisms of signal transduction.
GABAB receptors are distributed widely throughout the central nervous system, and research into their biogenesis and regulation has refined our understanding of G protein-coupled receptors. The sleuthing skills of pharmacologists nevertheless continue to be challenged by this important group of receptors.
Studies of neuronal gene regulation in health and disease are defining new levels of versatility in regard to the protein factors and gene elements that govern transcription. As research into the regulatory protein NRSF demonstrates, the molecular players of the gene regulatory stage can receive and change their roles according to cellular context.
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