Strontium Ranelate in Osteoporosis and Beyond: Identifying Molecular Targets in Bone Cell Biology
Table 1
Effects of Strontium Ranelate on Bone Cells In Vivo.
| Cell type | Effect | References |
|---|---|---|
| Osteoblasts (rat, mouse, human) | Increased cell proliferation | (23–28, 54, 60, 78) |
| Osteoblasts and progenitors (mouse) | Increased cell differentiation | (21, 28, 29, 54, 78) |
| Osteoblasts (mouse, human) | Increased cell survival | (26, 60) |
| Pre-osteoclasts (chicken, human) | Increased expression of OPG; decreased expression of RANKL | (21, 60, 61) |
| Osteoclasts (rabbit, mouse) | Decreased cell differentiation | (18, 19, 21, 60, 61) |
| Osteoclasts (human) | Decreased osteoclast activity; increased apoptosis | (20, 21) |
