LuXuRies of Lipid Homeostasis: The Unity of Nuclear Hormone Receptors, Transcription Regulation, and Cholesterol Sensing

  1. Yuan Zhang and
  2. David J. Mangelsdorf
  1. Department of Pharmacology Howard Hughes Medical Institute University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Dallas Tx 75390-9050
  1. DJM. E-mail{at}; fax 214-648-5419.


Cholesterol homeostasis is maintained by a regulatory network that controls both the acquisition and elimination of cholesterol. Recent studies have elucidated a mechanism by which cholesterol metabolism is transcriptionally regulated by several classes of orphan nuclear receptors. In particular, the liver X receptors, LXRα and LXRβ, appear to serve as key sensors of intracellular sterol levels by regulating the expression of genes that control cholesterol absorption, storage, transport, and elimination. LXRs are also involved in fatty acid metabolism by their ability to increase the expression of sterol regulatory element–binding protein 1c (SREBP-1c). These findings define LXRs as potential therapeutic targets for the treatment of lipid disorders.


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