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Ceramide-1-phosphate: The “missing” link in eicosanoid biosynthesis and inflammation
Figure 3.
SphK1 and CERK in mast cell functions. Crosslinking of FcεRI, the high-affinity IgE receptor on mast cells, results in translocation (to the cell membrane) and activation of sphingokinase-1 (SphK1). The resulting product, S1P, in turn activates S1P2 receptors, leading to mast cell degranulation. CERK may also regulate degranulation of mast cells.
