CALCIUM: A Role for Neuroprotection and Sustained Adaptation

Preservation of CA1 neurons and CA1 AMPA protein after 3×KA. A. Control photomicrographs of P20 silver stained section showing no argyrophilia. At P20 (A) and P30 (D) after 3×KA treatment, the CA1 was protected but CA3 damage shown as black staining was present. At P20 and P30, GluR1_A (B, E) and GluR2_B (C, F) protein levels were similar to controls (see Fig. 1⇑), except for in the CA3 region associated with cell loss (arrow). At P30, GluR1_A immunolabeling (G) was significantly decreased in CA1 whereas GluR2_B was increased (I). Steady levels of GluR1_A and GluR2_B were observed after 3×KA (H, J). Modified from (32, 45). Reprinted with permission.