REGENERATIVE PHARMACOLOGY: THE FUTURE IS NOW

Major signal transduction pathways that modulate myocyte tone. Aspects of these pathways could serve as a benchmark for phenotypic characterization of bioengineered muscle. [(+) denotes a positive or stimulatory effect; (−) denotes a negative or inhibitory effect. BK_Ca, the calcium-sensitive K channel (maxi-K), although clearly there are several types of K channels known to be present in detrusor myocytes; SR, sarcoplasmic reticulum; RyR, ryanodine receptor; PLC, phospholiapse C; DAG, diacylglycerol; PKC, protein kinase C; IP₃, inositol trisphosphate; MLC, myosin light chain; A, agonist; R, receptor; CPI-17, protein kinase C-potentiated protein phosphatase-1 inhibitory protein.]