Indian Journal of Human Genetics
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CASE REPORT
Year : 2011  |  Volume : 17  |  Issue : 3  |  Page : 235-237

Acute promyelocytic leukemia with unusual karyotype


1 Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore - 560029, India
2 Heamatology Unit, Kidwai Memorial Institute of Oncology, Bangalore - 560029, India
3 Department of Pedotric Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560029, India

Correspondence Address:
Prasannakumari
Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore - 560 029, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.92093

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Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21:), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML).


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